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Control of Proline Biosynthesis by Proline and Proline Analogues

Naturevolume 212pages7475 (1966) | Download Citation



MICRO-ORGANISMS prevent over-production of amino -acids by two mechanisms: (a) end-product inhibition of the action of the first specific enzyme in the biosynthetic sequence, and (b) inhibition of the synthesis of all the enzymes in the sequence (enzyme repression)1,2. A number of growth-inhibitory analogues of normal protein amino-acids, besides being incorporated into proteins, are capable of mimicking the corresponding amino-acid in operating these biosynthetic control mechanisms (see reviews by Cohen3 and by Fowden, Lewis and Tristram4).

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  1. Department of Botany, University College, London, W.C.1.

    •  & C. F. THURSTON


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