Abstract
MICRO-ORGANISMS prevent over-production of amino -acids by two mechanisms: (a) end-product inhibition of the action of the first specific enzyme in the biosynthetic sequence, and (b) inhibition of the synthesis of all the enzymes in the sequence (enzyme repression)1,2. A number of growth-inhibitory analogues of normal protein amino-acids, besides being incorporated into proteins, are capable of mimicking the corresponding amino-acid in operating these biosynthetic control mechanisms (see reviews by Cohen3 and by Fowden, Lewis and Tristram4).
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References
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TRISTRAM, H., THURSTON, C. Control of Proline Biosynthesis by Proline and Proline Analogues. Nature 212, 74–75 (1966). https://doi.org/10.1038/212074a0
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DOI: https://doi.org/10.1038/212074a0
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