Abstract
THERE is some evidence that in the guinea-pig, the oral administration of degraded carrageenin, a sulphated polysaccharide, causes a slight temporary reduction of gastric acidity in response to histamine1. We have had occasion to study the effect on gastric secretion when degraded carrageenin is administered subcutaneously. The results indicate that carrageenin parenterally has a pronounced inhibitory action on the acid secretory response to histamine but, somewhat paradoxically, not on the secretory response to ‘Histalog’ (betazole hydrochloride), a structural isomer of histamine.
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References
Anderson, W., Marcus, R., and Watt, J., J. Pharm. Pharmacol., 14, 119T (1962).
Dragstedt, C. A., Wells, J. A., and Rocha E. Silva, M., Proc. Soc. Exp. Biol. N.Y., 51, 191 (1942).
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WATT, J., EAGLETON, G. & MARCUS, R. Effect of Degraded Carrageenin on Gastric Secretion Stimulated by Histamine and ‘Histalog’. Nature 211, 989 (1966). https://doi.org/10.1038/211989a0
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DOI: https://doi.org/10.1038/211989a0
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