Abstract
IN previous work we showed that adenine nucleosides and nucleotides play an important part in the quantitative regulation of porphyrin biosynthesis. Administration of inosine or adenosine monophosphate (AMP) reduced significantly the excess porphyrin formation in rats caused by different toxic agents (for example, allylisopropyl-acetylcarbamide, hexachlorobenzene, 3,5-dicarbethoxy-1,4-dihydrocollidine, lead acetate and griseofulvin)1–3. On the other hand, porphyrin synthesis by illuminated suspensions of Rhodopseudomonas spheroides in Lascelles medium I was strongly inhibited by AMP, adenosine diphosphate (ADP) and adenosine triphosphate (ATP). ATP was found to provoke more than 90 per cent inhibition at a concentration of 3 mM.
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GAJDOS, A., GAJDOS-TÖRÖK, M., PALMA-CARLOS, A. et al. Porphyria induced in Rats by Orotic Acid and the Effect of Adenine-5′-monophosphoric Acid. Nature 211, 974–975 (1966). https://doi.org/10.1038/211974a0
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DOI: https://doi.org/10.1038/211974a0
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