Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Polyarteritis Nodosa-like Disease in Outbred Mice

Abstract

Helyer and Howie1 described a disease of NZB/BL × NZY/BL and NZB/BL × NZW/BL F1 hybrid mice closely resembling human systemic lupus erythematosus (SLE) in renal histology. A breeding nucleus of these mice was provided by Drs. F. and M. Bielschowsky and Dr. Howie, to allow confirmation of their histological findings. Similar lesions were found in NZB/BL mice, although the age of onset is later than in the B × W hybrids. Outbred albino Palmerston North (PN) mice, initially intended as controls, showed renal and arterial lesions more closely resembling human polyarteritis nodosa than SLE. A comparison of the two types of lesion is summarized in Table 1. Spontaneous arteritic lesions have been described in rats by Skold2 and in mink by Leader3. Deringer4 has described arteritis of the ovarian and small bowel arteries in BL/De mice, but generalized spontaneous arteritis in mice does not appear to have been described previously.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Helyer, B. J., and Howie, J. B., Nature, 197, 197 (1963).

    ADS  CAS  Article  PubMed  Google Scholar 

  2. Skold, Lab. Invest., 8, 1468 (1959).

    Google Scholar 

  3. Leader, R. W., Wagner, B. M., Henson, J. B., and Gorham, J. R., Amer. J. Path., 43, 33 (1963).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Deringer, M. K., Lab. Invest., 8, 1461 (1959).

    Google Scholar 

  5. Burnet, F. M., and Holmes, M. C., Nature, 194, 146 (1962).

    ADS  CAS  Article  PubMed  Google Scholar 

  6. Norins, L., and Holmes, M. C., J. Immunol., 93, 148 (1964).

    CAS  PubMed  Google Scholar 

  7. Friou, G. J., and Teague, T. O., Lab. and Clin. Med., 62, 875 (1963).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

WIGLEY, R., COUCHMAN, K. Polyarteritis Nodosa-like Disease in Outbred Mice. Nature 211, 319–320 (1966). https://doi.org/10.1038/211319a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/211319a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing