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Normal Human Serum Fluoride Concentrations

Abstract

RESULTS from a new method of analysis of fluoride from serum indicate that the generally accepted value for normal humans is too high by as much as a factor of ten. The average serum fluoride concentration of sixteen non-fasting individuals, all presumably drinking fluoridated water, was found to be 0.7 µM ± 0.4 S.D. (0.013 p.p.m.) and the average difference in duplicates was 0.18 µM. (The very low values found here for serum fluoride make p.p.m. an awkward unit. Therefore the shift has been made to the more useful and acceptable chemical concentration terms, mµmole (millimicromole) and µM (micromolar).) The generally accepted average serum fluoride value is 8 µM (0.15 p.p.m.) as found by Singer and Armstrong, regardless of the concentration of fluoride in the drinking water up to 130 µM (2.5 p.p.m.)1.

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TAVES, D. Normal Human Serum Fluoride Concentrations. Nature 211, 192–193 (1966). https://doi.org/10.1038/211192b0

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