Abstract
IMMUNOFLUORESCENCE provides a simple means of studying the species distribution of antigenic components of animal tissues1. The availability of gastrointestinal-specific antisera as immunohistological reagents prompted us to explore the distribution of gastrointestinal antigens in mammalian and other vertebrate fauna of Australia. Two types of sera were used. One, prepared in rabbits by immunization with microsomal material from fresh surgical specimens of human colonic mucosa, had been previously shown to react with an acid mucopolysaccharide component of human and some other mammalian gastrointestinal mucosal cells and with no other tissue in the body2. The other, obtained from patients with pernicious anaemia, contains naturally occurring autoantibody to human gastric parietal cells; this antibody has also been shown not to be species-specific3.
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References
Nairn, R. C., Ghose, T., Fothergill, J. E., and McEntegart, M. G., Nature, 196, 385 (1962).
Nairn, R. C., Fothergill, J. E., McEntegart, M. G., and Porteous, I. B., Brit. Med. J., i, 1788 (1962).
de Boer, W. G. R. M., Nairn, R. C., and Maxwell, A., J. Clin. Path., 18, 456 (1965).
Nairn, R. C., Fluorescent Protein Tracing, second ed. (Livingstone, Edinburgh, 1964).
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NAIRN, R., DE BOER, W. Species Distribution of Gastrointestinal Antigens. Nature 210, 960–962 (1966). https://doi.org/10.1038/210960a0
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DOI: https://doi.org/10.1038/210960a0
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