Abstract
A WIDE variety of emotional and physical stimuli result in increased adrenocortical activity. Thus plasma cortisol-levels rise in response to trauma, surgery, fever and hypoglycaemia1–3. This has been attributed to a stress control mechanism which depends on the integrity of a cerebro-hypothalamo-pituitary-adrenal pathway and overrides the normal ‘negative-feedback’ control mechanism4. An increased secretion of growth hormone has been shown during insulin and tolbutamide induced hypoglycaemia, during exercise and during acute or chronic starvation5–8. This has been attributed to an increased demand for energy substrates and to be mediated via the hypothalamus. The possible role of stress in relation to growth hormone release does not appear to have been considered.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Franksson, C., Gemzell, C. A., and Von Euler, U. S., J. Clin. Endocrinol., 14, 608 (1954).
Egdahl, R. H., J. Clin. Invest., 38, 1120 (1959).
Landon, J., Wynn, V., and James, V. H. T., J. Endocrinol., 27, 183 (1963).
Sydnor, K. L., and Sayers, G., Endocrinology, 55, 621 (1954).
Roth, J., Glick, S. M., Yalow, R. S., and Berson, S. A., Science, 140, 987 (1963).
Roth, J., Glick, S. M., Yalow, R. S., and Berson, S. A., Metabolism, 12, 577 (1963).
Hunter, W. M., and Greenwood, F. C., Brit. Med. J., i, 804 (1964).
Marks, V., Howorth, N., and Greenwood, F. C., Nature, 208, 686 (1965).
Mattingly, D., J. Clin. Path., 15, 374 (1962).
Hunter, W. M., and Greenwood, F. C., Biochem. J., 91, 43 (1964).
Hunter, W. M., Fonseka, C. C., and Passmore, R., Science, 150, 1051 (1965).
Landon, J., James, V. H. T., and Stoker, D., Lancet, ii, 1156 (1965).
Mirsky, I. A., Amer. J. Physiol., 204, 842 (1963).
Burt, R. L., Leake, N. H., and Dannenburg, W. N., Obst. and Gynecol., 23, 574 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GREENWOOD, F., LANDON, J. Growth Hormone Secretion in Response to Stress in Man. Nature 210, 540–541 (1966). https://doi.org/10.1038/210540a0
Issue Date:
DOI: https://doi.org/10.1038/210540a0
This article is cited by
-
Evaluation of stress induced by flight activity by measuring the hormonal response
Biofeedback and Self-Regulation (1996)
-
Thyrotropin-releasing hormone does not inhibit lysine vasopressin-induced growth hormone secretion in normal men
Experientia (1985)
-
Insulin-counteracting hormones: Their impact on glucose metabolism
Diabetologia (1983)
-
Biochemical changes after surgical stress in rabbits
The Japanese Journal of Surgery (1982)
-
Catecholamine, STH, Cortisol, Glucagon, Insulin und Sexualhormone bei körperlicher Belastung und Beta1-Blockade
Klinische Wochenschrift (1982)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
