Abstract
IT has been well established for many years that the effectiveness of ionizing radiation may be correlated with dose-rate1–4. The relative ineffectiveness of radiation at low dose-rates is generally regarded as resulting from the operation of intracellular repair or recovery mechanisms, which may act between successive damaging events, when an accumulation of these is required to give the effect under investigation. In most radiobiological investigations on mammals, or with mammalian cells, experimenters have used dose-rates of up to a few hundred rads per min, so that the duration of ‘acute’ doses is usually to be measured in minutes or tens of minutes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Canti, R. G., and Spear, F. G., Proc. Roy. Soc., B, 102, 92 (1927).
Spear, F. G., and Grimmett, L. G., Brit. J. Radiol., 6, 387 (1933).
Lea, D. E., Brit. J. Radiol., 11, 489 (1938).
Gray, L. H., and Scholes, M. E., Brit. J. Radiol., 24, 285 (1951).
Lindop, P., and Rotblat, J., in Cellular Basis and Aetiology of Late Somatic Effects of Ionizing Radiation, p. 313 (Academic Press, 1963).
Ainsworth, E. J., Leong, G. F., Kendall, K., Alpen, E. L., and Allbright, M. L., in Biological Effects of Neutron and Proton Irradiations, 2, 15 (Intern. Atomic Energy Agency, Vienna, 1964).
Quastler, H., Radiat. Res., 4, 303 (1956).
Batchelor, A., Bewley, D. K., Morrison, R., and Stevenson, J. A., Brit. J. Radiol., 32, 332 (1959).
Cameron, J. R., Daniels, F., Johnson, N., and Kenney, G., Science, 134, 333 (1961).
Elkind, M. M., Radiology, 74, 529 (1960).
Bateman, J. L., Bond, V. P., and Robertson, J. S., Radiology, 79, 1008 (1962).
Hall, E. J., and Bedford, J. S., Radiat. Res., 22, 305 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HORNSEY, S., ALPER, T. Unexpected Dose-rate Effect in the Killing of Mice by Radiation. Nature 210, 212–213 (1966). https://doi.org/10.1038/210212a0
Issue Date:
DOI: https://doi.org/10.1038/210212a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
