Abstract
RECENT investigations have shown that the genetic constitution of the host is of critical importance as regards the immune response to hapten poly-L-lysine conjugates1,2, random linear copolymers3 and reactivity in certain hyper-sensitivity phenomena such as experimental allergic encephalomyelitis4 and thyroiditis5. This information was obtained with guinea-pigs of inbred strains 2 and 13 which had been demonstrated by Bauer in 1958 (ref. 6) to be histocompatible. Investigations on arsanilic acid conjugates of amino-acid polymers7,8 have shown that these conjugates are antigenic in random-bred guinea-pigs. Accordingly, experiments were designed to assess the immune response of the inbred strains 2 and 13 to arsanilic acid conjugates of poly-L-lysine (ars-L) and poly-L-glutamic L-lysine L-tyrosine (ars-GLT).
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BEN-EFRAIM, S., LESKOWITZ, S. Antigenicity of Conjugates of Arsanilic Acid in Inbred Guinea-pigs. Nature 210, 1068–1069 (1966). https://doi.org/10.1038/2101068a0
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DOI: https://doi.org/10.1038/2101068a0
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