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Spinal Cord Hypothermia by Localized Perfusion Cooling


A NEW technique has been developed which will rapidly and selectively cool the mammalian spinal cord while the temperature of the body core remains near normothermic levels. This becomes specially relevant in the light of the utilization of profound hypothermic levels1 and isolated cerebral perfusion techniques in neurovascular surgery2,3. With this method both acute and chronic preparations can be used to investigate the neurophysiological and cardiovascular events associated with spinal cord cooling as well as to evaluate the efficacy of hypothermia in clinical situations associated with spinal cord trauma and disease.

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  1. Rehder, K., Kirklin, J. W., MacCarty, C. S., and Theye, R. A., Ann. Surg., 156, 882 (1962).

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  2. White, R. J., Albin, M. S., Verdura, J., Massopust, jun., L., and Meder, R., Proc. Seventeenth Ann. Conf. Engin. Med. Biol., 6, 85 (1964).

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  3. White, R. J., Albin, M. S., Verdura, J., Massopust, jun., L., and Meder, R., Clin. Res., 13, 224 (1965).

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ALBIN, M., WHITE, R., LOCKE, G. et al. Spinal Cord Hypothermia by Localized Perfusion Cooling. Nature 210, 1059–1060 (1966).

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