Abstract
ALTHOUGH considerable attention has been directed to the role of impaired release of liver triglyceride into plasma in the development of the fatty liver induced in rats by ethionine1,2, it seems unlikely that such a mechanism, by itself, adequately accounts for the fatty liver. Lombardi and Recknagel1 have presented evidence showing that ethionine impaired hepatic triglyceride release in both male and female rats; however, it is well known that the male is surprisingly resistant to the development of a fatty liver3. Observations that glucose administration either prevents3,4 or decreases5,6 hepatic triglyceride accumulation directed attention to the possibility that hypoglycaemia occurs after an injection of ethionine, thus serving as a stimulus for fat accumulation in the liver.
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COMBES, B., SCHENKER, S. Ethionine-induced Hypoglycaemia. Nature 209, 911–912 (1966). https://doi.org/10.1038/209911a0
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DOI: https://doi.org/10.1038/209911a0
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