Abstract
THREE polycyclic hydrocarbons—3-methylcholanthrene (3-MCA) (refs. 1–3), dibenz (a, h) anthracene (DBA) (ref. 4) and dibenzo (a, i) pyreue (3,4,9,10-dibenzpyrene; DBF) (ref, 5)—have so far been shown to induce tumours antigenic to their isogeneic and/or their autologous host. The immunity produced is weak and can. usually be overcome by a sufficiently large inoculum of tumour cells. Thus, tumours induced in inbred strains with these carcinogens take successfully on implantation into isogeneic mice, but give negative results in the allogeneic or random-bred strains6–9. Our investigations on the transplantability of the DBP-induced tumour into isogeneic and allogeneic mice agree with these findings. DBP-induced fibrosarcomata originally induced in strain A/Heston mice or BALB/c mice and transplanted into isogeneic hosts have been successfully transplanted, whereas the random-bred CRCD ♀ mouse was resistant to allografts of the induced tumour and we concluded that growth failure was due to an allograft response.
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WODINSKY, I., HELINSKI, A. & KENSLER, C. Enhancement of Transplantability of 3,4,9,10-Dibenzpyrene-induced Fibrosarcoma in Random-bred Mice. Nature 209, 414–415 (1966). https://doi.org/10.1038/209414a0
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DOI: https://doi.org/10.1038/209414a0
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