Failure to transfer Sensitivity to Skin Homografts by Means of ‘Immune’ Lymphoid Cells in Diffusion Chambers

Abstract

ALTHOUGH there has been a considerable number of reports dealing with the susceptibility of dissociated cellular homografts of many tissues, notably those derived from the lymphohaematopoietic system, to humoral isoantibodies¹, the majority of attempts to demonstrate that humoral factors play any significant part in the destruction of skin and other solid tissue homografts have failed². Indeed, most of the available evidence sustains the premise that a ‘cellular’ immunity is involved and that the demise of a homograft is causally related to its characteristic infiltration by mononuclear cells.