Abstract
STUDIES of the extensibility of quiescent cardiac muscle have been the cause of recurrent controversy. Starling's law of the heart relates the energy of contraction to the length the muscle fibres attain just prior to contraction. In studies of the regulation of cardiac contraction the assumption is made that measurement of pressure within the ventricle during diastole provides an accurate index of ventricular volume and that changes in pressure thus predict changes in fibre length1. This assumption requires that the compliance of ventricular muscle, that is, the change in length for a given change in force, remain constant throughout diastole in spite of changing conditions. Although there have been indications in the older literature that the compliance or ‘tone’ of the heart may change during diastole as a dynamic variable2, present interpretations of cardiac performance are based on the existence of constant diastolic extensibility3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Sarnoff, S. J., Physiol. Rev., 35, 107 (1955).
Meek, W. J., Physiol. Rev., 7, 259 (1927).
Mitchell, J. H., Linden, R. J., and Sarnoff, S. J., Circulat. Res., 8, 1100 (1960).
Hoffman, B. F., Bartelstone, H. J., Scherlag, B. J., and Cranefield, P. F., Bull. N.Y. Acad. Med., 41, 498 (1965).
Bartelstone, H. J., Scherlag, B. J., Hoffman, B. F., and Cranefield, P. F., Bull. N.Y. Acad. Med., 41, 616 (1965).
Sonnenblick, E. H., Frommer, P. L., and Braunwald, E., Bull. N.Y. Acad. Med., 41, 554 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SCHERLAG, B., BARTELSTONE, H., WYTE, S. et al. Variable Diastolic Ventricular Compliance : a General Property of Mammalian Cardiac Muscle. Nature 209, 1246–1248 (1966). https://doi.org/10.1038/2091246b0
Issue Date:
DOI: https://doi.org/10.1038/2091246b0
This article is cited by
-
Increase of myocardial oxygen consumption due to active diastolic wall tension
Basic Research in Cardiology (1984)
-
Die Kontraktionsausgangslage isolierter Froschventrikel unter erh�htem Calciumangebot
Pfl�gers Archiv f�r die Gesamte Physiologie des Menschen und der Tiere (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.