Abstract
COMPARED with other organs such as the heart and the brain, the human kidney has a copious blood-flow and a high oxygen consumption (weight for weight). In the secretion of urine, active energy-consuming processes play an important part, in addition to the purely physical processes of ultrafiltration and back diffusion. Hitherto, it has not been established whether this energy is made available by anaerobic or by aerobic metabolic processes. So far, only a correlation between oxygen consumption and sodium reabsorption has been demonstrated by Deetjen et al.1 and by Lassen et al.2 in animal experiments.
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References
Deetjen, P., and Kramer, K., Klin. Wschr., 38, 680 (1960).
Lassen, N. A., Munck, D., and Hess-Thaysen, J., Acta Physiol. Scand., 51, 371 (1961).
Gold, M., and Spitzer, J. J., Amer. J. Physiol., 206, 153 (1964).
Levy, M. N., Amer. J. Physiol., 202, 302 (1962).
Nieth, H., Durr, F., Eggstein, M., Höhmann, B., and Schollmeyer, P., Verh. Dtsch. Ges. Inn. Med., 70, 681 (1964).
Hohorst, H. J., in Methoden der Enzymat. Analyse Chemie (Weinheim, 1962).
Dole, V. P., and Meinertz, H., J. Biol. Chem., 235, 2595 (1960).
Bücher, Th., Czock, R., Lamprecht, W., and Latzko, E., in Methoden der Enzymat. Analyse Chemie (Weinheim, 1962).
Gey, F. K., Intern. Z. Vitaminforschg., 25, 21 (1953).
Barthelmai, W., and Czock, R., Klin. Wschr., 40, 585 (1962).
Van Slyke, D. D., and Neill, J. M., J. Biol. Chem., 61, 323 (1927).
Nieth, H., Stein, E., and Marx, H. H., Verh. Dtsch. Ges. Inn. Med., 70, 684 (1964).
Gottstein, U., Bernsmeier, A., and Sedlmeyer, J., Klin. Wschr., 41, 943 (1963).
Keul, J., Doll, E., Stein, H., Homburger, H., Kern, H., and Reindell, H., Pflügers Arch., 282, 43 (1965).
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NIETH, H., SCHOLLMEYER, P. Substrate-utilization of the Human Kidney. Nature 209, 1244–1245 (1966). https://doi.org/10.1038/2091244a0
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DOI: https://doi.org/10.1038/2091244a0
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