Abstract
THE finding that plasma erythropoietin titre in patients with an aplastic or hypoplastic bone marrow was higher than in patients with haemolytic anaemias despite similar haemoglobin concentration led Stohlman to postulate that the plasma erythropoietin level is related not only to the severity of the stimulus but also to the degree of erythroid activity of the bone marrow1. Jacobson et al.2 and Hammond et al.3 have suggested that erythropoietin may be consumed or degraded by actively proliferating erythrocytic elements.
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References
Stohlman, jun., F., and Brecher, G., Proc. Soc. Exp. Biol. and Med., 100, 40 (1959).
Jacobson, L. O., Goldwasser, E., and Gurney, C. W., in The Kinetic of Cellular Proliferation, edit. by Stohlman, jun., F., 344 (Grune and Stratton, New York, 1959).
Hammond, G. D., Ishikawa, A., and Keighley, G., in Erythropoiesis, edit. by Jacobson, L. O., and Doyle, M., 351 (Grune and Stratton, New York, 1962).
DeGowin, R. L., Hofstra, D., and Gurney, C. W., J. Lab. Clin. Med., 60, 846 (1962).
Naets, J. P., and Wittek, M., Nature, 206, 726 (1965).
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BOZZINI, C. Influence of the Erythroid Activity of the Bone Marrow on the Plasma Disappearance of Injected Erythropoietin in Dogs. Nature 209, 1140–1141 (1966). https://doi.org/10.1038/2091140b0
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DOI: https://doi.org/10.1038/2091140b0
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