Abstract
INVESTIGATIONS of muscular contraction in heavy water have shown that the rate-determining process involves proton transfer1. The magnitude of the effect suggests that more than one proton is involved. Varga2 has observed that fibres under isometric tension in the presence of adenosine triphosphate are relaxed when the temperature is lowered, an effect which has been attributed to the endothermicity of actomyosin formation. On the other hand, increasing the hydrostatic pressure results in contraction of intact muscle3–5.
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HORNE, R., JOHNSON, D. Proton Transfer Processes in Muscle : Pressure, Temperature and Isotope Effects. Nature 209, 82–83 (1966). https://doi.org/10.1038/209082a0
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DOI: https://doi.org/10.1038/209082a0
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