Abstract
ONE of the most striking effects of vitamin E deficiency is the acute muscular wasting seen in young rabbits raised on a tocopherol-free diet. Although this nutritional muscular dystrophy has been known for more than thirty years, its mechanism remains obscure. If impaired muscle protein synthesis were the cause of the wasting, one should expect that vitamin E-deficient animals would incorporate less of a given dose of amino-acid labelled with carbon-14 into muscle proteins when compared with vitamin E-supplemented animals. Surprisingly, Dinning et al.1 have found that dystrophic muscle incorporated more glycine-l-14C.
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References
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DIEHL, J. Effect of Vitamin E Deficiency on Uptake of Amino-acid and Incorporation in Isolated Rabbit Diaphragm. Nature 209, 75–76 (1966). https://doi.org/10.1038/209075a0
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DOI: https://doi.org/10.1038/209075a0
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