Abstract
THE life-cycle of poultry coccidia can be inhibited by certain p-aminobenzoic acid1–3, folic acid3–6 and thiamine7 antagonists. This knowledge led to our testing three known antagonists of another vitamin, nicotinamide, for anticoccidial activity. These substances were 3-acetylpyridine8, pyridine-3-sulphonamide9 and 6-aminonicotinamide10.
Similar content being viewed by others
Article PDF
References
Horton-Smith, C., and Boyland, E., Brit. J. Pharmacol., 1, 139 (1946).
Waletzky, E., and Hughes, C. O., Amer. J. Vet. Res., 7, 365 (1946).
Joyner, L. P., and Kendall, S. B., Brit. J. Pharmacol., 11, 454 (1956).
Lux, R. E., Antibiot. Chemother., 4, 971 (1954).
Joyner, L. P., and Kendall, S. B., Vet. Rec., 68, 468 (1956).
Kendall, S. B., and Joyner, L. P., Vet. Rec., 70, 632 (1958).
Rogers, E. F., Clark, R. L., Pessolano, A. A., Becker, H. J., Leanza, W. J., Sarett, L. H., Cuckler, A. C., McManus, E., Garzillo, M., Malanga, C., Ott, W. H., Dickinson, A. M., and Van Iderstine, A., J. Amer. Chem. Soc., 82, 2974 (1960).
Woolley, D. W., J. Biol. Chem., 157, 455 (1945).
McIlwain, H., Brit. J. Exp. Path., 21, 136 (1940).
Johnson, W. J., and McColl, J. D., Science, 122, 834 (1955).
Long, P. L., and Rowell, J. G., Lab. Pract., 7, 515 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BALL, S., WARREN, E. & PARNELL, E. Anticoccidial Activity of Nicotinamide Antagonists. Nature 208, 397 (1965). https://doi.org/10.1038/208397a0
Issue Date:
DOI: https://doi.org/10.1038/208397a0
This article is cited by
-
Anticoccidial riboflavine antagonists
Experientia (1977)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.