Abstract
SEVERAL adenohypophyseal hormones have been demonstrated to possess in vitro lipotropic activity; these include growth, adrenocorticotropic, thyrotropic, α-melanocyte-stimulating and β-melanocyte-stimulating hormones. Recently, Rudman, Astwood and their colleagues reported the preparation of Fraction H, peptides I and II, and showed these preparations to be lipotropic agents1,2. In the course of investigating a simplified procedure for the isolation of ACTH from sheep pituitary glands, we have obtained a lipotropic peptide3 which is chemically distinct from ACTH and other known adenohypophyseal hormones. In this communication, we wish to describe the isolation of another lipotropic peptide (designated as β-LPH) from sheep pituitaries. The complete amino-acid sequence of β-LPH will also be presented here.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Rudman, D., J. Lipid Res., 4, 119 (1963).
Friesen, H., Metabolism, 10 (Part 2), 1214 (1964).
Birk, Y., and Li, C. H., J. Biol. Chem., 239, 1048 (1964).
Spackman, D. H., Stein, W. H., and Moore, S., Anal. Chem., 30, 1190 (1958).
Gross, E., and Witkop, B., J. Biol. Chem., 237, 1856 (1962).
Edman, P., Acta Chem. Scand., 4, 277 (1950).
Harris, J. I., Nature, 184, 167 (1959).
Pickering, B. T., and Li, C. H., Biochim. Biophys. Acta, 74, 156 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HAO LI, C., BARNAFI, L., CHRÉTIEN, M. et al. Isolation and Amino-acid Sequence of β-LPH from Sheep Pituitary Glands. Nature 208, 1093–1094 (1965). https://doi.org/10.1038/2081093b0
Issue Date:
DOI: https://doi.org/10.1038/2081093b0
This article is cited by
-
Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation
Cellular and Molecular Life Sciences (2021)
-
Scotophobin resurrected as a neuropeptide
Nature (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.