Letter | Published:

Ultrastructure of Antibody-forming Cells

Naturevolume 207pages994995 (1965) | Download Citation



THE method of Jerne and Nordin for demonstrating individual antibody-forming lymphoid cells has been utilized to obtain quantitative information about the cellular changes during antibody formation1, to indicate transplantation immunity2 and to demonstrate antibody-forming cells in ‘tolerant’ animals3. Recently, this method has been combined with autoradiography to investigate the kinetics of antibody formation4. In the present studies the plaque method has been used to identify for study by electron microscopy individual cells which have released antibody.

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  1. 1

    Jerne, N. K., and Nordin, A. A., Science, 140, 405 (1963). Jerne, N. K., Nordin, A. A., and Henry, C., in Cell-bound Antibodies, edit. by Amor, B., and Koprowski, H., 109 (Wistar Inst. Press, Philadelphia, 1963).

  2. 2

    Friedman, H., Science, 145, 607 (1964).

  3. 3

    Rowley, D. A., and Fitch, F. W., J. Exp. Med., 120, 987 (1964); and unpublished results.

  4. 4

    Berglund, K., Nature, 204, 89 (1964).

  5. 5

    Rowley, D. A., and Fitch, F. W. (unpublished results).

  6. 6

    Nossal, G. J. V., Szenberg, A., Oda, G. L., and Austin, C. M., J. Exp. Med., 119, 455 (1964). Mellors, R. C., and Korngold, L., J. Exp. Med., 118, 387 (1963). Chiappino, G., and Pernis, B., Path. Microbiol., 27, 8 (1964).

  7. 7

    dePetris, S., Karlsbad, G., and Pernis, B., J. Exp. Med., 117, 849 (1963).

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  1. F. W. FITCH: John and Mary R. Markle scholar in academic medicine.

  2. D. A. ROWLEY: U.S. Public Health Service Senior Research Fellow.

  3. S. COULTHARD: Predoctoral trainee, supported by U.S. Public Health Service medical training grant 2-TI-AI 96–05 from the Department of Health, Education and Welfare, National Institutes of Health.


  1. Department of Pathology, University of Chicago

    • F. W. FITCH
    • , D. A. ROWLEY
    •  & S. COULTHARD


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