Letter | Published:

Simultaneous Chromatographic Separation and Infra-red Sample Preparation of Indole Acids

Naturevolume 207pages977978 (1965) | Download Citation



IN attempting to identify trace amounts of metabolites from biological fluids, the use of one of the most powerful tools of organic chemical analysis, infra-red spectroscopy, presents technical difficulties. The two major ones are: (a) a sample preparation technique for the characteristically polar compounds, and (b) sufficient purity to allow a resolvable spectrum.

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  1. 1

    Mandell, A. J., Sabbot, I. M., Mandell, M. P., and Kollar, E. J., Arch. Gen. Psychiat., 10, 229 (1964).

  2. 2

    Morgan, P. J., The Analyst, 86, 631 (1961).

  3. 3

    Krivis, A. F., Bronson, G. E., Struck, W. A., and Johnson, J. L., Microchem. J., 8, 277 (1961).

  4. 4

    Sloan, H. J., Anal. Chem., 35, 1556 (1963).

  5. 5

    Thomas, P., and Dwyer, J. J., Chromatog., 13, 366 (1963).

  6. 6

    Millipore Filter Corp. App. Man., ADM–70 (Bedford, Mass., 1963).

  7. 7

    Millich, F., and Becker, E. I., J. Org. Chem., 23, 1096 (1958).

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  1. Department of Psychiatry, University of California Medical Center, Los Angeles, 24



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