Letter | Published:

Resistance to Sigma Virus Infection in Drosophila

Naturevolume 207pages887888 (1965) | Download Citation

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Abstract

Drosophila melanogaster is subject to infection by the sigma virus, either by virus carried in the fly gametes or by extracts from infected flies. Infected flies somehow become ‘CO2-sensitive’ and thereafter are fatally poisoned if subjected to a dose of CO2, which is merely anaesthetic to virus-free flies. Plus1 showed that the time lag (incubation period) between a sigma injection and the onset of CO2-sensitivity is a measure of the injected dose, and sigma extracts are now usually titred by using them as inocula and measuring the resultant incubation period in recipient adult flies.

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References

  1. 1

    Plus, N., Bull. Biol., 88, 248 (1954).

  2. 2

    Brun, G., Doctoral dissertation, Paris (1963).

  3. 3

    Wu, J. H., and Wildman, G., Nature, 199, 1015 (1963).

  4. 4

    Burnet, F., Principles of Animal Virology (Academic Press, New York, 1960).

  5. 5

    Seecof, R. L., Cold Spring Harb. Symp. Quant. Biol., 27, 501 (1962).

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Affiliations

  1. Department of Biology, City of Hope Medical Center, Duarte, California

    • R. L. SEECOF

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https://doi.org/10.1038/207887b0

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