Letter | Published:

Haemolytic Activity of Suspensions of Different Silica Modifications and Inert Dusts

Naturevolume 207pages874875 (1965) | Download Citation



RECENTLY, Harley and Margolis1 reported haemolytic activity of amorphous silica particles of sizes larger than 5 mµ. In the course of an investigation on the possible role of complement (C′) in the cytotoxicity of quartz, our experiments revealed a specific haemolytic effect of buffered saline suspensions of this mineral. Using corundum (α-Al2O3) and anatase (TiO2) of the same surface area as quartz, significantly less haemolysis was found2.

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  1. 1

    Harley, J. D., and Margolis, J., Nature, 189, 1010 (1961).

  2. 2

    Stalder, K., Beitr. Silikose-Forsch. (in the press).

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    Strecker, F. J., Beitr. Silikose-Forsch., S. Bd., 4, 121 (1960).

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    Strecker, F. J., Beitr. Silikose-Forsch., S. Bd., 6, 55 (1965).

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    Bohn, E., and Stöber, W., Beitr. Silikose-Forsch., S. Bd., 6, 27 (1965).

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    Schlipköter, H.-W., and Brockhaus, A., Klin. Wschr., 39, 1182 (1961).

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    Brown, E. A., J. Cell. Comp. Physiol., 50, 49 (1957).

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    Claude, A., Adv. Protein Chem., 5, 423 (1949).

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  1. Silicosis Research Group, Max-Planck-Society, Göttingen, Germany

    • K. STALDER
    •  & W. STÖBER


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