Abstract
IN 1961, Gaarder et al.1 reported that adenosine diphos-phate (ADP) causes human blood platelets to aggregate. Born et al.2,3 described a method by which the aggregation of platelets may be followed quantitatively. They confirmed the results of Gaarder and described inhibition of the ADP-effect by 2-chloroadenosine and other substituted nucleosides4. Lately, some more results on this subject have been published5–7, but the mechanism of platelet aggregation is still unknown.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gaarder, A., Jonsen, J., Laland, S., Hellem, A., and Owren, P. A., Nature, 192, 531 (1961).
Born, G. V. R., and Cross, M. J., J. Physiol., 168, 178 (1963).
Clayton, S., Born, G. V. K., and Cross, M. J., Nature, 200, 138 (1963).
Born, G. V. R., Nature, 202, 95 (1964).
Gaarder, A., and Laland, S., Nature, 202, 909 (1964).
Born, G. V. R., and Cross, M. J., J. Physiol., 170, 397 (1964).
Markwardt, F., and Hoffmann, A., Naturwiss., 51, 388 (1964).
Schievelbein, H., and Werle, E., Psychopharmacologia, 3, 35 (1962).
Schievelbein, H., and Zitzelsberger, B., Med. Exp., 11, 239, 247 (1964).
Singh, J., and Oester, Y. T., Fed. Proc., 20, 168 (1961).
Wenzel, D. G., and Singh, J., J. Pharm. Sci., 51, 875 (1962).
Shimamoto, T., Asian Med. J., 3, 479 (1960).
Werle, E., and Trautschold, I., Z. Physiol. Chem., 325, 48 (1961).
Trautschold, I., and Rüdel, G., Klin. Wschr., 41, 297 (1963).
Frey, E. K., Kraut, H., and Werle, E., Kallikrein (Padutin), (Enke-Verlag, Stuttgart, 1950).
Gokcen, M., and Yunis, E., Nature, 200, 590 (1963).
Marx, R., Clemente, P., Werle, E., and Appel, W., Blut, 5, 367 (1959).
Marx, R., Clemente, P., Werle, E., and Appel, W., Blut, 9, 164 (1963).
Thies, H. A. . Discussion remark in Thromt. et Diathesis Haemorrhagica, 8, Supp. 2, 105.
Werle, E., Hochstrasser, K., Trautschold, I., and Leysath, G., Z. Physiol. Chem., 337, 286 (1964).
Schievelbein, H., Acta Haematologica, 33, 110 (1965).
Jokay, I., Kassay, L., and Kiss, A., Experientia, 20, 315 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WERLE, E., SCHIEVELBEIN, H. Activity of Nicotine and Inactivity of Kallikrein and Kallidin in Aggregation of Blood Platelets. Nature 207, 871–872 (1965). https://doi.org/10.1038/207871a0
Issue Date:
DOI: https://doi.org/10.1038/207871a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
