Letter | Published:

Effect of Dihydrostreptomycin on Tissue Lipid of Guinea-pigs

Naturevolume 207pages869870 (1965) | Download Citation

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Abstract

ANTIBIOTICS are known to have profound effects on nucleic acids and protein biosynthesis. Coniglio and Bell1 reported that when antibiotics are administered orally to rats there is a significant increase in the incorporation of 14C-acetate into hepatic fatty acids. Chatterjee et al.2 observed that dihydrostreptomycin significantly influences the lipid metabolism of intestine and whole body of rats. The neurotoxic effects of dihydrostreptomycin on prolonged use in tuberculosis treatment and other infections are well known3. The present work was undertaken to study the effects of DHS on lipid changes in various tissues of guinea-pigs.

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References

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    Coniglio, J. G., and Bell, E. J., J. Biol. Chem., 226, 805 (1957).

  2. 2

    Chatterjee, K. P., Sinha, K. K., and Banerjee, S., J. Sci. Indust. Res., 21, C, 110 (1959).

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    Glorig, A., Ann. Otol. Rhin. Laryng., 60, 327 (1951).

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    Folch, J., Lees, M., and Sloane-Stanley, G. H., J. Biol. Chem., 226, 497 (1957).

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    Hanel, H. K., and Dam, H., Acta Chem. Scand., 9, 677 (1955).

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    Sperry, W. W., and Webb, M., J. Biol. Chem., 187, 97 (1950).

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    Misra, U. K. (unpublished results).

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Affiliations

  1. Department of Biochemistry and Isotopes, V. P. Chest Institute, Delhi University, Delhi, 7, India

    • RAMA MISRA
    • , U. K. MISRA
    •  & T. A. VENKITASUBRAMANIAN

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https://doi.org/10.1038/207869a0

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