Letter | Published:

Changes in the Quantity and Nature of Collagen in Rabbit Skin as a Function of Age

Naturevolume 207pages865866 (1965) | Download Citation



THE process of ageing is known to be accompanied by changes in the chemistry of connective tissue. In general collagen seems to accumulate with increasing age. Nevertheless, this is only true for the insoluble fraction, since the soluble collagens, which represent the newly formed molecules, decrease with age, reflecting the lowered rate of synthesis. Most of the work in this connexion has been reviewed in detail by Harkness1.

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  1. 1

    Harkness, R. D., Biol. Rev., 36, 339 (1961).

  2. 2

    Nimni, M. E., and Bavetta, L. A., Proc. Soc. Exp. Biol. and Med., 117, 618 (1964).

  3. 3

    Bakerman, S., Nature, 196, 375 (1962).

  4. 4

    Woessner, jun., J. R., Arch. Biochem. Biophys., 93, 440 (1961).

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  1. Department of Biochemistry and Nutrition, School of Dentistry, University of Southern California, Los Angeles

    • M. E. NIMNI
    • , E. DE GUIA
    •  & L. A. BAVETTA


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