Letter | Published:

Solubility of Renal Stones

Naturevolume 207page861 (1965) | Download Citation

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Abstract

THE cause of renal stone formation is unknown. Of the many current theories, majority opinion probably favours a ‘supersaturation’ mechanism, in which the urine concentrations of the ions of a poorly soluble salt exceed the ‘precipitation product’ for that particular salt, thereby causing spontaneous nucleation and subsequent growth of salt crystals.

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References

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    Smothers, W. J., and Siegel, L. H., J. Urol., 71, 647 (1954).

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    Prien, E. L., and Frondel, C., J. Urol., 57, 949 (1947).

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    Lagergren, C., J. Urol., 87, 199 (1962).

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    MacGregor, J., and Brown, W. E., Nature, 205, 359 (1965).

  5. 5

    MacGregor, J., and Nordin, B. E. C., J. Biol. Chem., 235, 1215 (1960).

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Affiliations

  1. University Department of Medicine, Gardiner Institute, Western Infirmary, Glasgow

    • J. MACGREGOR
    • , B. E. C. NORDIN
    •  & W. G. ROBERTSON

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https://doi.org/10.1038/207861a0

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