Letter | Published:

Synthesis of Ribonucleic Acid by the X-Chromosomes of Drosophila melanogaster and the Problem of Dosage Compensation

Naturevolume 207pages785786 (1965) | Download Citation

Subjects

Abstract

INVESTIGATIONS of the expression of various sex-linked genes in Drosophila have shown that for most of them their phenotypic manifestation is identical in male and female. Stern1, Muller2 and later Muller et al.3 by use of mutations such as bobbed and apricot in various doses showed that the identity and equality of genie expression between the two sexes are not associated, a priori, with the development of sex, but rather involves a system of genes, plus and minus modifiers, which regardless of sex tends to repress the action of extra doses of sex-linked genes. Muller proposed the name ‘dosage compensation’ for this effect and concluded that for each sex-linked gene there is a set of ‘compensator genes’4.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Stern, C., Biol. Zbl., 49, 261 (1929).

  2. 2

    Muller, H. J., Proc. Sixth Intern. Congr. Genet., 1, 213 (1932).

  3. 3

    Lieb, M., M.A. thesis, Indiana (1942) (quoted in ref. 5).

  4. 4

    Muller, H. J., Harvey Lecture, Ser. XIII, 1947–1948, 1, 165 (1950).

  5. 5

    Cock, A. G., Gen. Res., 5, 354 (1964).

  6. 6

    Lyon, M. F., Gen. Res., 4, 93 (1963).

  7. 7

    Russel, L. B., Science, 140, 976 (1963).

  8. 8

    Stern, C., Canad. J. Gen. and Cytol., 2, 105 (1960).

  9. 9

    Rudkin, G. T., in The Nueleohistones, edit. by Bonner, J., and Ts'o, P (Holden Day Inc., 1964).

  10. 10

    Dobzhansky, Th., Chromosoma, 8, 691 (1957).

  11. 11

    Aronson, J. F., Rudkin, G. T., and Schultz, J., J. Histochem. Cytochem., 2, 458 (1954).

  12. 12

    Schmid, W., Cytogenetics, 2, 175 (1963).

Download references

Author information

Author notes

    • ARDHENDU S. MUKHERJEE

    Present address: Department of Zoology, University of Calcutta, 35, Bally-gunge Circular Road, Calcutta, 19, India

Affiliations

  1. Max-Planck-Institut für Biologie, Tübingen, West Germany

    • ARDHENDU S. MUKHERJEE
    •  & W. BEERMANN

Authors

  1. Search for ARDHENDU S. MUKHERJEE in:

  2. Search for W. BEERMANN in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/207785a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.