Letter | Published:

Antiviral Activity of p-Nitrobenzylphosphonic Acid

Naturevolume 207pages784785 (1965) | Download Citation



pNITROBENZYLPHOSPHONIC ACID (I), first prepared by Litthauer1 in 1889, has attracted little attention from biologists or biochemists. In a recent investigation2 this compound was found to inhibit the activity of intestinal alkaline phosphatase. In continuation of our programme of work on phosphonic acids in various biological systems2–4 we have investigated the effect of p-nitrobenzylphosphonic acid (p-NBP) on the propagation of encephalomyocarditis virus (EMC) in vitro and in vivo and found it to possess antiviral activity.

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  1. 1

    Litthauer, S., Ber., 22, 2144 (1889).

  2. 2

    Kochman, M., Mastalerz, P., and Wolna, E., Arch. Immunol. Ther. Exp., 12, 106 (1964).

  3. 3

    Wieczbrek, Z., Mastalerz, P., and Kochman, M., Acta Biochim. Polon. (in the press).

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    Mastalerz, P., Arch. Immunol. et Ther. Exp., 7, 201 (1959).

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    Tytell, A. A., and Neuman, R. E., Proc. Soc. Exp. Biol. and Med., 113, 343 (1963).

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    Inglot, A. D. (unpublished results).

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    Barski, G., and Tsunataro, Kishida, Virology, 14, 299 (1961).

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    Umbreit, W. W., in Umbreit, W. W., Burris. R. H., and Stauffer, J. F., Manometric Techniques (Burgess Publishing Co., 1959).

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    Barker, S. B., and Summerson, W. H., J. Biol. Chem., 138, 535 (1941).

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    King, E. J., and Wootton, J. D. P., in Micro-Analysis in Medical Biochemistry (J. and A. Churchill, Ltd., 1956).

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Author information


  1. Department of Virology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław

  2. Department of Biochemistry, Medical School of Wroclaw

  3. Department of Organic Chemistry I, Institute of Technology, Wrocław



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