Abstract
THE cheek pouch of the Syrian hamster (Mesocricetus auratus) has been used in many investigations involving circulation1–3, hetero- and homo-transplantability of normal tissues and neoplasms4–7, histochemistry8,9 and chemical carcinogenesis3,8–10. Salley10 showed that experimental squamous cell carcinomata could be produced in the hamster's cheek pouch by painting with 9,10-dimethyl-l,2-benzanthracene. Delarue et al.3 reported that they obtained fibrosarcomata nine months after subcutaneous implantation of paraffin pellets containing DMBA in the cheek pouch. We have reported11 that a single subcutaneous injection of 3,4,9,10-dibenzpyrene at the nape of the neck induced fibrosarcomata in the hamster. The primary purpose of this investigation was to determine whether the subcutaneous tissue of the hamster's cheek pouch was as susceptible to the action of the chemical carcinogen.
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WODINSKY, I., HELINSKI, A. & KENSLER, C. Experimental Tumorigenesis in the Hamster Cheek Pouch. Nature 207, 770–772 (1965). https://doi.org/10.1038/207770b0
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DOI: https://doi.org/10.1038/207770b0
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