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Comparison of T-Wave Changes in the Dog following Intravenous Administration of Chlorpromazine and Fluphenazine

Naturevolume 207pages765766 (1965) | Download Citation



As early as 1954, flattening of the T-wave following chlorpromazine administration to anaesthetized dogs was reported by Moyer et al.1. Marked T-wave changes were also noted by Melville2 in 1958 following the administration of chlorpromazine to dogs under similar conditions. Other investigators have noted electrocardiographic alterations in man after parenteral administration of chlorpromazine. Undesirable effects on the electrocardiogram and ballistocardiogram by chlorpromazine were observed by Eliakim et al.3. Kupatz4 recommended that chlorpromazine should not be used to tranquillize children prior to electrocardiogram determinations because the compound induced changes in the T-wave. Minor T-wave changes in the electrocardiograms of several patients treated with chlorpromazine were noted by Moyer et al.1.

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  1. 1

    Moyer, J. H., Kent, B., Knight, R., Morris, G., Huggins, R., and Handley, C. A., Amer. J. Med. Sci., 227, 283 (1954).

  2. 2

    Melville, K. I., Arch. int. Pharmacodyn, 115, 278 (1958).

  3. 3

    Eliakim, M., Izak, G., and Braun, K., Cardiologia, 32, 177 (1958).

  4. 4

    Kupatz, H., Mschr. Einderheilk., 104, 335 (1956).

  5. 5

    Graupner, K. I., and Murphree, O. D., J. Neuropsychiat., 5, 344 (1964).

  6. 6

    Kelly, H. G., Fay, J. E., and Laverty, S. G., Can. Med. Assoc., J., 89, 546 (1963).

  7. 7

    Nat. Inst. Ment. Hlth., Psychopharmacol. Serv. Cent., Collab. Study Grp., Arch. Gen. Psychiat., 10, 246 (1964).

  8. 8

    Piala, J. J., High, J. P., Hassert, jun., G. L., Burke, J. C., and Craver, B. N., J. Pharmacol., 127, 55 (1959).

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  1. Squibb Institute for Medical Research, New Brunswick, New Jersey

    • G. L. HASSERT JUN.
    • , A. E. PETERSON
    •  & J. C. BURKE


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