Letter | Published:

Action of Angiotensin on Sympathetic Nerve Endings in Isolated Blood Vessels

Naturevolume 207pages764765 (1965) | Download Citation



THE recent experimental findings1,2 of a diminished effect of administered angiotensin on blood pressure after acute sympathectomy or pretreatment with reserpine have directed attention to a possible relationship between the effects of angiotensin and the sympathetic nerve system. In dogs, McCubbin and Page3 described an effect of angiotensin on the sympathetic nervous system resulting in an enhanced response to agents and procedures which cause release of endogenous noradrenaline. Later, Lewis4 observed an angiotensin-induced release of catecholaminas from the suprarenal medulla of cats. In connexion with this finding he tentatively discussed an action of angiotensin at the vascular wall by local liberation of catecholamines from the sympathetic nerve endings. The two kinds of experiments (a and b) presented here were undertaken to obtain further information on the relationship between angiotensin and the sympathetic vasomotor action.

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    Zimmerman, B. G., Circulation Res., 11, 780 (1962).

  2. 2

    Baum, Th., J. Pharmacol. Exp. Ther., 141, 30 (1963).

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    McCubbin, J. W., and Page, I. H., Circ. Res., 12, 553 (1963).

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    Lewis, G. P., Canad. Med. Assoc. J., 90, 302 (1964).

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    Bertler, A., Carlsson, A., and Rosengren, E., Acta Physiol. Scand., 44, 273 (1958).

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    MacMillan, W. H., Brit. J. Pharmacol., 14, 385 (1959).

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    Muscholl, E., Brit. J. Pharmacol., 16, 352 (1961).

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    Bejrablaya, D., Burn, J. H., and Walker, J. M., Brit. J. Pharmacol., 13, 461 (1958).

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    Takenaka, F., Jap. J. Pharmacol., 13, 274 (1963).

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  1. First Department of Physiology of the University of the Saar, 665 Homburg-Saar, Western Germany

    • A. DISTLER
  2. Second Medical Department, University Hospital, 665 Homburg-Saar, Western Germany

    • H. LIEBAU
    •  & H. P. WOLFF


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