Letter | Published:

A Common Mode of Antiviral Action for Ammonium Ions and Various Amines

Naturevolume 207pages664665 (1965) | Download Citation

Subjects

Abstract

AMMONIUM ions and various aliphatic amines have been reported1–4 to inhibit the growth of influenza virus in tissue culture. Recently, 1-adamantanamine was reported5 to inhibit the multiplication of certain strains of influenza virus by slowing or blocking the penetration of virus into the host cells. In this communication we present results showing that ammonium ions and various aliphatic amines inhibit influenza virus growth by the same mechanism as 1-adamantanamine.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Jensen, E. M., and Liu, O. C., Proc. Soc. Exp. Biol. and Med., 107, 834 (1961).

  2. 2

    Jensen, E. M., Force, E. E., and Unger, J. B., Proc. Soc. Exp. Biol. and Med., 107, 447 (1961).

  3. 3

    Eaton, M. D., Low, I. E., Scala, A. R., and Uretsky, S., Virology, 18, 102 (1962).

  4. 4

    Jensen, E. M., and Liu, O. C., Proc. Soc. Exp. Biol. and Med., 112, 456 (1963).

  5. 5

    Davies, W. L., Grunert, R. R., Haff, R. F., McGahen, J. W., Neumayer, E. C., Paulshock, M., Watts, J. C., Wood, T. R., Hermann, E. C., and Hoffmann, C. E., Science, 144, 862 (1964).

  6. 6

    Salk, J. E., J. Immunol., 49, 87 (1944).

  7. 7

    Johnson, C. A., Pekas, D. J., and Winzler, R. J., Science, 143, 1051 (1964).

  8. 8

    Aminoff, D., Biochem. J., 81, 384 (1961).

  9. 9

    Dales, S., and Choppin, P. W., Virology, 18, 489 (1962).

Download references

Author information

Affiliations

  1. Experimental Therapeutics Research, Lederle Division, American Cyanamid Co., Pearl River, New York

    • R. D. FLETCHER
    • , J. E. HIRSCHFIELD
    •  & M. FORBES

Authors

  1. Search for R. D. FLETCHER in:

  2. Search for J. E. HIRSCHFIELD in:

  3. Search for M. FORBES in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/207664a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.