Letter | Published:

A Common Mode of Antiviral Action for Ammonium Ions and Various Amines

Naturevolume 207pages664665 (1965) | Download Citation



AMMONIUM ions and various aliphatic amines have been reported1–4 to inhibit the growth of influenza virus in tissue culture. Recently, 1-adamantanamine was reported5 to inhibit the multiplication of certain strains of influenza virus by slowing or blocking the penetration of virus into the host cells. In this communication we present results showing that ammonium ions and various aliphatic amines inhibit influenza virus growth by the same mechanism as 1-adamantanamine.

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    Jensen, E. M., and Liu, O. C., Proc. Soc. Exp. Biol. and Med., 112, 456 (1963).

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    Davies, W. L., Grunert, R. R., Haff, R. F., McGahen, J. W., Neumayer, E. C., Paulshock, M., Watts, J. C., Wood, T. R., Hermann, E. C., and Hoffmann, C. E., Science, 144, 862 (1964).

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  1. Experimental Therapeutics Research, Lederle Division, American Cyanamid Co., Pearl River, New York

    • R. D. FLETCHER
    •  & M. FORBES


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