Abstract
A MARKED cellular hyperplasia occurs in the rat spleen in response to a single intravenous injection of a particulate antigen1–3. This hyperplasia is predominantly manifested in the red pulp, which exhibits a striking increase in the number of actively mitotic, large pyroninophilic cells within 2 days after antigen administration. The proliferation of these cells, which have been shown to be intimately associated with antibody formation in the rat4,5 as well as in other species6, reaches a maximum on about the fourth day after antigen. Later, their number rapidly diminishes so that by the ninth day the spleen has largely regained its pre-stimulation pattern and few if any of these cells appear to differentiate locally into plasma cells.
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References
Fitch, F. W., Barker, P., Soules, K. H., and Wissler, R. W., J. Lab. Clin. Med., 42, 598 (1953).
Gunderson, C. H., Juras, D., LaVia, M. F., and Wissler, R. W., J. Amer. Med. Assoc., 180, 1038 (1962).
Wissler, R. W., Fitch, F. W., LaVia, M. F., and Gunderson, C. H., J. Cell. Comp. Physiol., Supp. 1, 50, 265 (1957). (a) Wissler, R. W., Fitch, F. W., and LaVia, M. F., Ann. N.Y. Acad. Sci., 88, 134 (1960).
Fitch, F. W., Wissler, R. W., LaVia, M., and Barker, P., J. Immunol., 76, 151 (1956).
Wissler, R. W., Frazier, L. F., Soules, K. H., Barker, P., and Bristow, E. C., Amer. Med. Assoc. Arch. Path., 62, 62 (1956).
Coons, A. H., Leduc, E. H., and Connolly, J. M., J. Exp. Med., 102, 49 (1955).
Langevoort, H. L., Lab. Invest., 12, 106 (1963).
Wissler, R. W., Robson, M. J., Fitch, F., Nelson, W., and Jacobson, L. O., J. Immunol., 70, 379 (1953).
Pelc, S. R., Intern. J. Appl. Rad., 1, 172 (1956).
Nossal, G. J. V., and Mäkelä, O., Lab. Invest., 10, 1094 (1961).
Schooley, J. C., Bryant, B. J., and Kelly, L. S., in The Kinetics of Cellular Proliferation, edit. by Stohlman, jun., F., 208 (Grune and Stratton, Inc., New York, 1959).
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CANNON, D., WISSLER, R. Migration of Spleen Cells into the Blood Stream following Antigen Stimulation of the Rat. Nature 207, 654–655 (1965). https://doi.org/10.1038/207654a0
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DOI: https://doi.org/10.1038/207654a0
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