Letter | Published:

Mechanism of the Inhibitory Effect of Adenine Nucleotides on Porphyrin Synthesis by Rhodopseudomonas spheroides

Naturevolume 207pages640641 (1965) | Download Citation

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  • A Corrigendum to this article was published on 30 April 1966

Abstract

EXCESS biosynthesis of porphyrins is strongly decreased by some adenine nucleosides and nucleotides (inosine, 5′ AMP, 5′ ADP, 5′ ATP) in vivo as well as in vitro1–3. Experiments with Rhodopseudomonas spheroides have shown that ATP is the most active of these adenine derivatives, determining a more than 90 per cent inhibition2,3 in a concentration of 3 m.moles/l. of medium. On the other hand, it was established that this effect is confined to the step of ALA formation2,3.

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References

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    Gajdos, A., and Gajdos-Török, M., Lancet, ii, 175 (1961).

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    Gajdos, A., and Gajdos-Török, M., Bull. Soc. Chim. Biol., 45, 1227 (1963).

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    Shemin, D., Ciba Found. Symp., Porphyrin Biosynthesis, 4 (J. and A. Churchill, London, 1955).

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    Granick, and Urata, G., J. Biol. Chem., 238, 821 (1963).

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    Kikuchi, G., Kumar, A., Talmage, P., and Shemin, D., J. Biol. Chem., 233, 1241 (1958).

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  1. Clinique Médicale de 1'Hôtel-Dieu, Parvis de Notre-Dame, Paris

    • A. GAJDOS
    •  & M. GAJDOS-TÖRÖK

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https://doi.org/10.1038/207640b0

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