Letter | Published:

Species Specificity in Reaction between Renin and Angiotensinogen

Naturevolume 207page636 (1965) | Download Citation

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Abstract

ANGIOTENSIN, the most potent pressor substance known, strongly suspected as a cause of renal hypertension, is an octapeptide formed from angiotensinogen by the action of renin. It has long been thought that only primate renins are capable of acting on human angiotensinogen as reviewed by Braun-Menéndez et al.1.

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References

  1. 1

    Braun-Menéndez, E., Fasciolo, J. C., Leloir, L. F., Muñoz, J. M., and Taquini, A. C., Renal Hypertension, 113 (Springfield: Thomas, 1946).

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    Boucher, B., Veyrat, R., de Champlain, J., and Genest, J., Canad. Med. Assoc. J., 90, 194 (1964).

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    Skeggs, jun., E. T., Marsh, W. H., Kahn, J. R., and Shumway, N. P., J. Exp. Med., 100, 363 (1954).

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    Peart, W. S., Biochem. J., 59, 300 (1955).

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    Haas, E., Lamfrom, H., and Goldblatt, H., Arch. Biochem. Biophys., 48, 256 (1953).

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    Cohn, E. J., Strong, L. E., Hughes, jun., W. L., Mulford, D. J., Ashworth, J. N., and Taylor, H. L., J. Amer. Chem. Soc., 68, 459 (1946).

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    Arakawa, K., and Bumpus, M. F., J. Amer. Chem. Soc., 83, 728 (1961).

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Affiliations

  1. Research Institute of Angiocardiology, Kyushu University School of Medicine, Fukuoka, Japan

    • KIKUO ARAKAWA
    • , MISAKO NAKATANI
    •  & MOTOOMI NAKAMURA

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https://doi.org/10.1038/207636a0

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