Abstract
SOLID-PHASE peptide synthesis was conceived and developed with the view of eventually automating the synthesis of polypeptides1,2. In principle the process has certain characteristics which lend themselves to mechanization, and by exploitation of these properties an apparatus has now been constructed which performs automatically all the manipulations involved in the synthesis of a polypeptide chain.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
A general process for the development of peptide-based immunoassays for monoclonal antibodies
Cancer Chemotherapy and Pharmacology Open Access 20 January 2010
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Merrifield, R. B., J. Amer. Chem. Soc., 85, 2149 (1963).
Merrifield, R. B., Endeavour, 24, 3 (1965).
Merrifield, R. B., Biochemistry, 3, 1385 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MERRIFIELD, R., STEWART, J. Automated Peptide Synthesis. Nature 207, 522–523 (1965). https://doi.org/10.1038/207522a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/207522a0
This article is cited by
-
A general process for the development of peptide-based immunoassays for monoclonal antibodies
Cancer Chemotherapy and Pharmacology (2010)
-
Bradykinin in Solid-phase Peptide Synthesis
International Journal of Peptide Research and Therapeutics (2007)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
