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Automated Peptide Synthesis

Abstract

SOLID-PHASE peptide synthesis was conceived and developed with the view of eventually automating the synthesis of polypeptides1,2. In principle the process has certain characteristics which lend themselves to mechanization, and by exploitation of these properties an apparatus has now been constructed which performs automatically all the manipulations involved in the synthesis of a polypeptide chain.

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References

  1. Merrifield, R. B., J. Amer. Chem. Soc., 85, 2149 (1963).

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  2. Merrifield, R. B., Endeavour, 24, 3 (1965).

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  3. Merrifield, R. B., Biochemistry, 3, 1385 (1964).

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MERRIFIELD, R., STEWART, J. Automated Peptide Synthesis. Nature 207, 522–523 (1965). https://doi.org/10.1038/207522a0

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