Mosaicism for Trisomy 17–18 and Trisomy 13–15 in Man

Abstract

TRISOMY for two chromosomes of the normal chromosome complement has been found in several human subjects. The chromosomes most often involved in these double trisomic states have been the X-chromosome1,2 and chromosomes of the pairs 13–153, 17–181,4 and 212–4. In addition, male subjects with 48 chromosomes have been described in whom one extra chromosome was an X-chromosome, giving the sex chromosome constitution XXY, together with true trisomy for an autosome5,6. Hitherto, trisomies 13–15 and 17—18 have not been found in one individual and all the reported cases of double trisomy have apparently had only one cell line.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Uchida, I. A., Lewis, A. J., Bowman, J. M., and Wang, H. C., J. Pediat., 60, 498 (1962).

  2. 2

    Day, R. W., Wright, S. W., Koons, A., and Quigley, M., Lancet, ii, 154 (1963).

  3. 3

    Becker, K. L., Burke, E. C., and Albert, A., Proc. Mayo Clin., 38, 242 (1963).

  4. 4

    Gagnon, J., Katyk-Longtin, N., de Groot, J. A., and Barbeau, A., Un. méd. Can., 90, 1220 (1961).

  5. 5

    Ford, C. E., Jones, K. W., Miller, O. J., Mittwoch, U., Penrose, L. S., Ridler, M., and Shapiro, A., Lancet, i, 709 (1959).

  6. 6

    Haylock, J., Fitzgerald, M., and Danks, D. M. (personal communication).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

BAIKIE, A., GARSON, O. & BIRRELL, R. Mosaicism for Trisomy 17–18 and Trisomy 13–15 in Man. Nature 207, 1419–1420 (1965). https://doi.org/10.1038/2071419a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.