Immunological Significance of Lysosomes within Lymphocytes in vivo

Abstract

RECENT reports1,2 have demonstrated the presence of lysosome-like particles in human peripheral blood lymphocytes and have shown that these increase in size and number in tissue culture following stimulation with phytohaemagglutinin. These changes appear to precede the transformation of the small lymphocytes into cells which synthesize RNA and eventually undergo mitosis. In both these reports1,2 it is suggested that these lysosomes are in some way involved in the initiation of cell division.

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References

  1. 1

    Allison, A. C., and Malucci, L., Lancet, ii, 1371 (1964).

  2. 2

    Hirschhorn, R., Kaplan, J. M., Goldberg, A. F., Hirschhorn, K., and Weissmann, G., Science, 147, 55 (1965).

  3. 3

    Turk, J. L., and Stone, S. H., in Cell-bound Antibodies, edit. by Amos, B., and Koprowski, H., 51 (Wistar Institute Press, Philadelphia, 1963).

  4. 4

    Oort, J., and Turk, J. L., Brit. J. Exp. Path., 46, 147 (1965).

  5. 5

    Balfour, B. M., Cooper, E. H., and Alpen, E. L., Immunology, 8, 230 (1965).

  6. 6

    Holt, S. J., Exp. Cell Res., Supp., 7, 1 (1959).

  7. 7

    Bitensky, L., Quart. J. Micro. Sci., 104, 193 (1963).

  8. 8

    Diengdoh, J. V., Quart. J. Micro. Sci., 105, 73 (1964).

  9. 9

    Nelson, D. S., and Boyden, S. V., Immunology, 6, 264 (1963).

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DIENGDOH, J., TURK, J. Immunological Significance of Lysosomes within Lymphocytes in vivo. Nature 207, 1405–1406 (1965). https://doi.org/10.1038/2071405a0

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