Inhibition of Gastric Motility by a Commercial Duodenal Mucosal Extract containing Cholecystokinin and Pancreozymin

Abstract

IN the course of the search for the hormone which results in inhibition of gastric secretion and motility after fat has entered the duodenum, the ability of duodenal extracts to inhibit the motility of denervated gastric pouches has become crucial. The presence of fat in the duodenum inhibits the spontaneous motility of Heidenhain pouches1, but many duodenal extracts which inhibit acid secretion will not do this. Extracts of duodenal mucosa containing secretin2 and even more conclusively extracts containing cholecystokinin/pancreozymin3 inhibit gastric acid secretion.

References

  1. 1

    Farrell, J. I., and Ivy, A. C., Amer. J. Physiol., 76, 227 (1926).

  2. 2

    Greenlee, H. B., Longhi, E. H., Guerrero, J. D., Nelson, T. S., El Bedri, A. L., and Dragstedt, L. R., Amer. J. Physiol., 190, 396 (1957).

  3. 3

    Gillespie, I. E., and Grossman, M. I., Gut, 5, 342 (1964).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

JOHNSON, L., MAGEE, D. Inhibition of Gastric Motility by a Commercial Duodenal Mucosal Extract containing Cholecystokinin and Pancreozymin. Nature 207, 1401 (1965). https://doi.org/10.1038/2071401a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.