Foetal Uptake of Radiocalcium in Tetracycline-treated Rats


IN a recent communication we reported that the skeletal uptake of injected calcium-45 in young rats was not affected by dose levels of oxytetracycline appreciably exceeding those generally used in medical practice1. We have now extended this line of enquiry to a study of foetal radiocalcium uptake since others have reported that the tetracyclines can markedly interfere with the calcification of embryonic mineralized tissues in a number of animal species2,3. The details of this investigation are as follows:

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LIKINS, R., PAKIS, G. Foetal Uptake of Radiocalcium in Tetracycline-treated Rats. Nature 207, 1394–1395 (1965).

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