Dehydrogenation of trans-trans Farnesol by Horse Liver Alcohol Dehydrogenase

Abstract

Christophe and Popjak1 have recently reported that a number of prenols2 could serve as substrates for horse liver alcohol dehydrogenase (LADH) but they could not act as substrates for yeast alcohol dehydrogenase. This high degree of specificity of the prenols for LADH led the same authors to propose that the physiological role of the enzyme is connected primarily with the metabolism of intermediates of sterol biosynthesis and of similar natural products, and only fortuitously with dealing with man's social habit of consuming ethanol.

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References

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WALLER, G. Dehydrogenation of trans-trans Farnesol by Horse Liver Alcohol Dehydrogenase. Nature 207, 1389–1390 (1965). https://doi.org/10.1038/2071389b0

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