Abstract
AN insoluble fraction capable of absorbing the agglutinating and mouse-protecting antibodies from Brucella suis antisera was isolated in this laboratory from sonically disintegrated Br. suis1. This fraction was assumed to be part of the bacterial cell wall. Further experiments2,3 showed that cell walls and cell wall fragments from Br. abortus and Br. suis protected mice against challenge with Br. abortus (strain ‘2308’) more effectively than intact cells. The immunizing activity of Brucella cell walls was confirmed in several other laboratories4–6.
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References
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RASOOLY, G., OLITZKI, A. & SULITZEANU, D. An Immunogenic Fraction extracted from Brucella abortus Cell Wails by Phenol. Nature 207, 1308–1309 (1965). https://doi.org/10.1038/2071308a0
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DOI: https://doi.org/10.1038/2071308a0
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