Stimulation of Mast Cell Production in Lymph Nodes of the Rat by Pyrrolizidine Alkaloids

Abstract

MAST cells are known to increase in some tissues under certain conditions often associated with an immunological component. Well-known examples are in the skin in the vicinity of induced epitheliomas in mice1 and associated with proliferative changes in the thymus of NZB mice2. In lymph nodes, where under normal conditions mast cells occur in small numbers only, Miller3 observed an increase in mast cell numbers after injection of Salmonella antigens, and Takeoka et al.4 noted a significant increase in mast cells in the lungs and mediastinal lymph nodes in rats being fed seeds of Crotalaria spectabilis or the pyrrolizidine alkaloid, monocrotaline, isolated from this plant.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Bloom, G. D., Ann. N.Y. Acad. Sci., 103, 53 (1963).

  2. 2

    Burnet, F. M., J. Path. Bact., 89, 271 (1965).

  3. 3

    Miller, J. J., III (personal communication).

  4. 4

    Takeoka, O., Angevine, D. M., and Lalich, J. J., Amer. J. Path., 40, 545 (1962).

  5. 5

    Culvenor, C. C. J., Dann, A. T., and Dick, A. T., Nature, 195, 570 (1962).

  6. 6

    Culvenor, C. C. J., Drummond, L. J., and Price, J. R., Austral. J. Chem., 7, 277 (1954).

  7. 7

    Culvenor, C. C. J., Austral. J. Chem., 7, 287 (1954).

  8. 8

    Bull, L. B., Dick, A. T., and McKenzie, J. S., J. Path. Bact., 75, 19 (1958).

  9. 9

    Bull, L. B., and Dick, A. T., J. Path. Bact., 78, 483 (1959).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

DIENER, E., DICK, A. Stimulation of Mast Cell Production in Lymph Nodes of the Rat by Pyrrolizidine Alkaloids. Nature 207, 1305–1306 (1965). https://doi.org/10.1038/2071305b0

Download citation

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.