Stimulation of Mast Cell Production in Lymph Nodes of the Rat by Pyrrolizidine Alkaloids


MAST cells are known to increase in some tissues under certain conditions often associated with an immunological component. Well-known examples are in the skin in the vicinity of induced epitheliomas in mice1 and associated with proliferative changes in the thymus of NZB mice2. In lymph nodes, where under normal conditions mast cells occur in small numbers only, Miller3 observed an increase in mast cell numbers after injection of Salmonella antigens, and Takeoka et al.4 noted a significant increase in mast cells in the lungs and mediastinal lymph nodes in rats being fed seeds of Crotalaria spectabilis or the pyrrolizidine alkaloid, monocrotaline, isolated from this plant.

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DIENER, E., DICK, A. Stimulation of Mast Cell Production in Lymph Nodes of the Rat by Pyrrolizidine Alkaloids. Nature 207, 1305–1306 (1965).

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