Abstract
AN impressive body of evidence indicates that cardiovascular reactivity either to sympathetic nerve stimulation or to injected catecholamines is considerably decreased in adrenalectomized animals1. The administration of adrenocortical hormones to such animals either improves or restores to normal the ability of the cardiovascular system to respond either to sympathetic nerve activity or to the injection of adrenaline or noradrenaline1. These considerations suggest that one result of stress-induced adrenocortical secretion in normal animals might be an enhanced response of the cardiovascular system to the catecholamines. In support of this idea, it has been reported2 that hydrocortisone increased the response of rabbit aorta to noradrenaline in vitro. Such potentiation could be caused by a decreased tissue-binding (that is, functional inactivation) of administered noradrenaline produced by the steroid. This suggestion was investigated by examining the influence of administered hydrocortisone on the sub-cellular distribution of tritiated noradrenaline in the rabbit heart.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ramay, E., Physiol. Rev., 37, 163 (1957).
Besse, J. C., and Bass, A. D., Fed. Proc., 23, 457 (1964).
Gillis, C. N., J. Pharmacol., 146, 54 (1964).
Dohan, F. C., and Lukens, F. D. W., Endocrinology, 42, 244 (1948).
Potter, L. T., and Axelrod, J., J. Pharmacol., 142, 291 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GILLIS, C. Altered Cardiac Retention of Exogenous Noradrenaline produced by Stress in Young Rabbits. Nature 207, 1302–1304 (1965). https://doi.org/10.1038/2071302a0
Issue Date:
DOI: https://doi.org/10.1038/2071302a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.