Abstract
THERE is ample evidence1–20 that when a fixed dose of drug is administered in a fixed multiple-dose regimen, the blood levels of drug eventually reach a steady state in which the blood level time curve during any dosage interval is the same as it is in the preceding and in the following dosage interval. One may define the equilibrium state as that in which input of drug to the ‘body’ is equal to output of drug from the ‘body’ in a given dosage interval. The same equilibrium state will be reached when the initial dose is higher than the maintenance dose3,4.
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WAGNER, J., NORTHAM, J., ALWAY, C. et al. Blood Levels of Drug at the Equilibrium State after Multiple Dosing. Nature 207, 1301–1302 (1965). https://doi.org/10.1038/2071301a0
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DOI: https://doi.org/10.1038/2071301a0
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