Adenosine Triphosphate and Muscular Contraction and Relaxation


THERE are three observations which suggest that diminution of the adenosine triphosphate (ATP) content of muscle leads to contraction: (a) the ATP and creatine phosphate (CP) content of isolated striated muscle is about 5 times that of smooth muscle1, and the latter always shows a state of partial contraction or tonus; (b) diminution of the ATP content of smooth muscle leads to contraction, and increase to relaxation2; (c) adrenaline, which causes relaxation of smooth muscle, increases the ATP content of muscle by about 70 per cent in the first 15 sec3.


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SINGH, I. Adenosine Triphosphate and Muscular Contraction and Relaxation. Nature 207, 1300 (1965).

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