Interaction of 4-Dimethylaminoazobenzene and Dietary Fat in the Regulation of Hepatic Microsomal Ascorbic Acid Synthesis


AN increase in urinary ascorbic acid excretion in rats has been demonstrated to occur after an injection of 4-dimethylaminoazobenzene (DAB) and also after the injection of several methylated derivatives of this carcinogen1. Other types of compounds, such as chloretone, aminopyrine, meprobamate and phenylbutazone, also increase the urinary excretion of ascorbic acid in rats2,3. It has been suggested that these compounds stimulate the biosynthesis of glucuronic acid as an adaptive response for detoxication processes, and that some of the glucuronic acid is then utilized for the synthesis of ascorbic acid.

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RAY, S., MORIN, R. Interaction of 4-Dimethylaminoazobenzene and Dietary Fat in the Regulation of Hepatic Microsomal Ascorbic Acid Synthesis. Nature 207, 1294–1295 (1965).

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